Fig. 6.
Prostaglandins partially reproduce the effects of TRPA1 activation on DSM contractions. A, B: Representative recordings of the contractions of DSM strips from control rats in response to the application of prostaglandins (A) F2α (PGF2α,) and (B) E2 (PGE2). C, D: As in panels A and B, respectively, but for DSM strips from diabetic animals. E, F: Quantification of the actions of PGF2α and PGE2 (both at 10 µM) on the amplitude of the EFS-contractions (E) and of the tone (F) in control (dark grey columns) and diabetic (light grey columns) DSM strips (mean ± s.e.m., n=6 in both cases); "*" P<0.05 in diabetes compared with respective controls. Other explanations and designations are the same as in Fig. 1A; note that in diabetic DSM, the contractile effects of the prostaglandins are amplified.