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. 2015 May 22;51:10–21. doi: 10.1540/jsmr.51.10

Fig. 6.

Fig. 6.

Effects of the ROCK inhibitor on bovine ciliary muscle strips. (a) A representative tension trace showed that Y-27632 (20 µmol/l) attenuated CCh-induced contraction of the BCM. Addition of 3 µmol/l okadaic acid did not cause further change. It did not tend to reverse when Y-27632 and okadaic acid were removed. (b) Observed tension was normalized to that of pre-contraction with CCh (white column). Y-27632 decreased the tension by 60.3 ± 2.3% (pale gray column, n = 6, P < 0.01 vs. control). Addition of okadaic acid did not cause any change at either 1µmol/l (dark gray column, 60 ± 4.6%) or 3 µmol/l (black column, 55.7 ± 4.3%). Statistical assessments by paired t-test did not show significant differences in Y-27632 with 1 or 3 µmol/l okadaic acid (P = 0.12, n = 3 and P = 0.11, n = 3, respectively) compared with Y-27632 alone.