Table 4.

Estimated Haplotype Frequency of the TPH2 SNPs and the Results of Haplotype Analysis in Responders and Nonresponders

Gene/rs#	Haplotype	RES	NR	RES-freq(%)	NR-freq(%)	P	P**	OR (95%CL)
Total group (n = 281)
TPH2/rs2171363, rs1487278	A-A	87.9	48	21.54	31.58	.01153	.03996	0.6959 (0.4259–1.136)
	A-G*	121.1	46	29.68	30.26
	G-A	195.1	58	47.82	38.16
TPH2/rs1386494, rs2171363, rs1487278	A-A-A	28.85	17	70.70	11.18
	G-A-A	58.71	31	14.39	20.39
	G-A-G*	120.3	46	29.48	30.26
	G-G-A	195.4	58	47.90	38.16	.0364	.1239	1.986 (1.018–3.872)
SSRI subgroup (n = 164)
TPH2/rs2171363, rs1487278	A-A	44.53	32	19.53	32.00	.01203	.02697	0.5526 (0.2898–1.054)
	A-G*	65.47	26	28.72	26.00
	G-A	115.5	42	50.65	42.00