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. 2016 Dec 2;57(6):668–676. doi: 10.1093/jrr/rrw037

Table 4.

ROC curve analysis of DVH parameters in relation to Grade 3 chronic GI complications

AUC 95% CI Optimal threshold Chi–square
Value Sensitivity/specificity (%) P value Odds ratio
Small bowel loops V5 0.81 0.73–0.88 430 ml 72.2/82.1 <0.001 8.91
V10 0.82 0.74–0.89 360 ml 77.8/76.1 <0.001 8.30
V15 0.82 0.75–0.89 395 ml 72.2/82.1 <0.001 12.21
V20 0.83 0.75–0.90 330 ml 83.3/73.5 <0.001 8.30
V30 0.87 0.81–0.93 300 ml 83.3/77.8 <0.001 31.51
V40 0.89 0.82–0.95 225 ml 94.4/70.9 <0.001 19.16
V45 0.88 0.82–0.94 235 ml 88.9/74.4 <0.001 27.20
Mean dose 0.73 0.63–0.83 36.7 Gy 61.1/72.6 0.02 3.36
gEUD (n = 0.15) 0.75 0.65–0.84 46.0 Gy 66.7/65.9 <0.01 5.26
Bowel bag V30 0.69 0.59–0.79 940 ml 72.2/57.3 0.06 3.24
V40 0.72 0.63–0.82 850 ml 66.7/62.4 <0.01 7.10
V45 0.71 0.62–0.81 800 ml 72.2/60.7 0.01 4.59
Mean dose 0.66 0.54–0.79 35.3 Gy 61.1/69.2 0.16 2.15
gEUD (n = 0.15) 0.71 0.61–0.82 45.2 Gy 65.8/66.7 0.11 3.28

ROC = receiver operating characteristics, DVH = dose–volume histogram, GI = gastrointestinal, AUC = area under the ROC curve, CI = confidence interval, gEUD = the generalized equivalent dose.