Figure 7.
The target spectrum of SdsR sRNA in Salmonella. (A) SdsR accumulates in the cell as two distinct species: a full-length and a processed version (SdsR+31; scissors indicate the sRNA processing site). SdsR employs two independent target sites (dark and light green boxes) to regulate 18 target mRNAs identified in this study from transcriptomic analysis; repression of ompD mRNA was confirmed previously (40). The target repertoire of SdsR includes genes encoding membrane proteins (red symbols), proteins with metabolic activity (yellow symbols), DNA-binding proteins (blue symbols) and factors not associated with any of these categories (gray). (B) Dense network of SdsR and the major transcriptional regulators, CRP, RpoS (σS) and StpA. Genes regulated by SdsR were obtained from Table 1, RpoS- and CRP-controlled genes (E. coli) were extracted from RegulonDB (106), and StpA-associated genes were collected from (100).