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. 2016 Aug 3;44(21):10091–10105. doi: 10.1093/nar/gkw684

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Transcription-associated trans-determinants promote nucleosome positioning. (A) Stereotypical nucleosome arrays with heavy MNase digestion. 15,841 well-modeled genes are ranked from high to low by their expression levels and divided into 10 quantiles. Nucleosome distribution around TSS is aggregated over all genes in a quantile. Inset: zoom in on the +1, +2 and +3 nucleosomes. (B) Stereotypical nucleosome arrays with light MNase digestion. (C) Nucleosome positioning with different levels of gene expression. Called nucleosomes in the gene body are ranked from high to low by the expression levels of their associated genes, and divided into 10 quantiles. Normalized distributions of degrees of nucleosome positioning are plotted for all 10 quantiles separately. (D) Nucleosome positioning with different levels of Pol II association. (E) Nucleosome positioning with different levels of H3K4 methylation. (F) Relationship between transcription-associated trans-determinants and well-positioned nucleosomes.