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. 2016 Aug 3;44(21):10091–10105. doi: 10.1093/nar/gkw684

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Splice sites are flanked by positioned nucleosomes. (A) Composite analysis of nucleosome positioning in MAC (red), MIC (blue), and in vitro (magenta) (25), aligned to the dyads of the called nucleosomes flanking splice sites (left: GT, right: AG). The distribution of exon% (pale blue), calculated as the probability that a particular position containing exons, is superimposed. See Methods for details. (B) Composite analysis of nucleosome occupancy in MAC (red), MIC (blue), and in vitro (magenta) (25), aligned to the dyads of the called nucleosomes flanking splice sites (left: GT, right: AG). The distribution of GC% (green) is superimposed. Note the correlation between nucleosome arrays near splice sites and oscillations of GC%. (C) Distribution of called nucleosomes in the gene body, according to their distances from TSS (x-axes) and splice sites (y-axes; top: GT; bottom: AG). Note the clustering of nucleosome distribution along both the x- and y-axes (point density in color scales). See Supplemental File S1 for a compilation of properties of called nucleosomes.