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. 2016 Oct 13;44(21):10017–10030. doi: 10.1093/nar/gkw922

Table 1. Expression of histone deacetylases in cancers.

Histone deacetylase Upregulated in cancer Downregulated in cancer
Class I HDAC1 Colorectal (5–7), Stomach (5,8,9), Oesophagus (5,10), Breast (5,11,12), Ovaries (5), Lung (5), Pancreas (5), Thyroid (5), Prostate (13–15), Melanoma (16)
HDAC2 Colorectal (5,6,17–19), Stomach (5,20), Oesophagus (5), Breast (5), Ovaries (5), Lung (5), Pancreas (5), Thyroid (5), Prostate (15), Melanoma (16)
HDAC3 Colorectal (5), Stomach (5), Oesophagus (5), Breast (5,11), Ovaries (5), Lung (5,21), Pancreas (5), Thyroid (5), Prostate (15)
HDAC8 Neuroblastoma (22)
Class IIA HDAC4 Colorectal (5), Stomach (5,23), Oesophagus (5), Breast (5,7), Ovaries (5,24), Lung (5), Pancreas (5), Thyroid (5) Glioblastoma (33)
HDAC5 Colorectal (7,25), Melanoma (26), Liver (27)
HDAC7 Colorectal (7)
Class IIB HDAC6 Oral (28), Melanoma (26)
Class III SIRT1 Skin (81), Colorectal (34)
SIRT6 Myeloma (29) Pancreas (35), Colorectal (35)
SIRT7 Breast (30), Thyroid (31), Liver (32)