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. 2016 Oct 13;44(21):10480–10490. doi: 10.1093/nar/gkw931

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Interactions between CPS-6 and DNA at the atomic level. (A, C) Schematic diagram showing the hydrogen bond network between CPS-6 and DNA for protomers A and B, respectively. An Mg²⁺ ion is bound in the ββα-metal motif and bridges CPS-6 and DNA in each protomer. (B, D) Close-up of the hydrogen bonding at the CPS-6-DNA interface for protomers A and B, respectively. (E) The DNA-binding residues of human, bovine, fruit fly and yeast EndoG are conserved. (F) Interactions between CPS-6 and DNA have a structural impact on the DNA-binding residues, Arg117, Arg146 and Arg181.