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. 2016 Jul 8;12(11):2847–2854. doi: 10.1080/21645515.2016.1203496

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Figure 1. — Antibody responses and protection against dental caries in S. mutans challenged rat after immunization. Rats were challenged with S. mutans and then immunized with PBS, 3.5 μg KF, 5 μg rPAc, 3.5 μg KF plus 5 μg rPAc, 8.5 μg KF-rPAc at 4 weeks interval. (A and B), rPAc-specific serum IgG and salivary IgA at 2 weeks after the second boost. (C), Total caries score 4 weeks after the second boost. (D and E), KF-specific serum IgG and salivary IgA at 2 weeks after the second boost. (*, p <0.05; **, p < 0.01; ***, p < 0.001)