Table 3.
Overview of adenovirus-based influenza vaccines.
| Vector | Model | Antigen | Modification | Subtype | Reference |
|---|---|---|---|---|---|
| Adenoviruses |  |
HA | n/a | H3N2, H5N1, H7N7, H9N2 | 191,193-195,199,201-204,206 |
| HA | Soluble head | H1N1 | 198 | ||
| HA | Glycan shielded | H5N1 | 207 | ||
| NP | n/a | H1N1, H5N1 | 192,208,209,214 | ||
| M2 | Consensus | n/a | 180 | ||
| HA/NP | n/a | H5N1, H7N7, H9N2 | 206 | ||
| HA/NA | n/a | H1N1 | 211 | ||
| NP/M2 | n/a | H1N1 | 216 | ||
| NP/M2 | Consensus | H1N1 | 210 | ||
| HA/NA/M1 | n/a | H1N1, H5N! | 213 | ||
| |
|
NP/M1/M2 |
miRNAs |
H1N1 |
211 |
 |
HA | n/a | H5N1 | 203,215 | |
| NP | n/a | H5N1 | 215 | ||
| M2 | n/a | H5N1 | 215 | ||
| HA/NA | Consensus | H1N1 | 212 | ||
| NP/M2 | n/a | H1N1, H5N1 | 215,216 | ||
| |
|
HA/NP/M2 |
n/a |
H5N1 |
215 |
 |
HA | n/a | H1N1, H3N2 | 196,200 | |
| NP | n/a | H3N2 | 196 | ||
| |
|
HA/NP |
n/a |
H3N2 |
196 |
| |
 |
HA |
n/a |
H5N1, H7N3 |
202,205 |
 |
HA | n/a | H1N1, H5N1 | 187,188,190 | |
| |
|
NP/M1 |
n/a |
H3N2 |
189 |
| AAV | |
HA | n/a | H1N1 | 222 |
| HA | Broadly neutralizing ab | n/a | 223,224 | ||
| NP | n/a | H1N1 | 222 | ||
| M1 | n/a | H1N1 | 222 | ||
| |
|
HA/NP/M1 |
n/a |
H1N1 |
222 |
|
HA | Broadly neutralizing ab | n/a | 224 |