Table S1.

Crystallographic data collection, refinement, and structure validation statistics

	AurA/N-Myc complex
Lattice parameters
Space group	P32 2 1
Cell dimensions
a, b, c, Å	86.52, 86.52, 92.21
α, β, γ, degrees	90.00, 90.00, 120.00
Data collection
Resolution range, Å	74.93–1.72 (1.76–1.72)*
Rmerge, %	6.3 (74.3)*
I/σI	19.8 (3.4)*
Completeness, %	100 (100)*
Redundancy	9.7 (9.7)*
Refinement
Resolution, Å	74.3–1.72
No. reflections	42,820
Rwork/Rfree	17.62/19.51
No. atoms
Protein	2,362
ADP/Mg2+	29
Water	197
Mean B-factors
Protein	28.09
ADP/Mg2+	19.16
Water	37.17
Wilson B-factor	25.63
Rmsd
Bond lengths, Å	0.005
Bond angles, degrees	1.043
MolProbity analysis
All-atom clash-score	2.34
Rotamers outliers, %	0
Ramachandran outliers, %	0
Ramachandran favored, %	97.25
MolProbity score	1.15

^*Values in parentheses refer to the highest-resolution shell.