Fig. S3.

A CpG module not associated with clinical activity is enriched in fundamental, nonimmune cell functions. (A) Functional enrichment analysis of the CpG module #31, mainly associated with age. The top 20 enriched GO terms (FDR-adjusted P < 0.01) are shown, ranked by P value. The black vertical line indicates an FDR-adjusted threshold of P = 0.01. (B and C) Percentage methylation of the prototypical module eigengene (B) and of three representative CpG sites (C) from module #31, in relation to age.