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. 2016 Nov 15;113(48):13762–13767. doi: 10.1073/pnas.1609939113

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Fig. 4. — Comparisons of ¹⁹F NMR STD results as a function of saturation times in various regions of NaChBac. (A) The linker region (S129, ●; L150, ▪), (B) the extracellular surface region (S208, ▼; L179, ♦), (C) the selectivity filter region (T189, ▲), and the PHE residues () in the pore region (F224, F227) and other regions of NaChBac. The filled and open symbols represent data from −CF₃ and −CF₂ moieties of isoflurane, respectively. The STD (%) uncertainties were calculated from the signal/noise ratios in the ¹⁹F STD spectra. The solid lines represent the best fit of the experimental data by Eq. 1 (Methods). The fitting results are provided in Table 1.

Inline graphic — Comparisons of ¹⁹F NMR STD results as a function of saturation times in various regions of NaChBac. (A) The linker region (S129, ●; L150, ▪), (B) the extracellular surface region (S208, ▼; L179, ♦), (C) the selectivity filter region (T189, ▲), and the PHE residues () in the pore region (F224, F227) and other regions of NaChBac. The filled and open symbols represent data from −CF₃ and −CF₂ moieties of isoflurane, respectively. The STD (%) uncertainties were calculated from the signal/noise ratios in the ¹⁹F STD spectra. The solid lines represent the best fit of the experimental data by Eq. 1 (Methods). The fitting results are provided in Table 1.