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Factor-free codon selection by aa-tRNA. In the absence of EF-Tu, aa-tRNA binds to a metastable preaccommodation state of the posttranslocation ribosome with association rate constant knf, from which it proceeds to A-site accommodation with rate constant kpep or dissociates with rate constant qnf. Notations c and nc in rate constants stand for cognate and noncognate reaction, respectively.
