Skip to main content
. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Dent Clin North Am. 2017 Jan;61(1):93–110. doi: 10.1016/j.cden.2016.08.008

Figure 4. Schematic diagram of molecular mechanisms that govern reparative dentin formation by CH or HCSCs at the MPC.

Figure 4

CH and HCSCs release hydroxyl group (OH−) and increase local pH at the MPC, creating alkaline environment that induces anti-bacterial activity and potentially promotes odontogenic mineralization. CH and HCSCs also release calcium ions (Ca2+), eliciting intracellular signaling pathways that ultimately promote odontogenic differentiation and mineralization.