Table 5.
The three most frequently reported drugs per type of ADRs according to MedDRA system organ class (SOCs) (suspect and interacting drugs only)
| SOCs | Total n | Drug | n | Drug | n | Drug | n |
|---|---|---|---|---|---|---|---|
| Blood and lymphatic system disorders | 587 | Zidovudine | 239 | Nevirapine | 62 | Lamivudine | 48 |
| Injury, poisoning and procedural complications | 527 | Phytomenadione | 173 | Chlorhexidine | 31 | Zidovudine | 22 |
| General disorders and administration site conditions | 478 | Phytomenadione | 50 | Chlorhexidine | 24 | Solutions for parenteral nutrition | 17 |
| Investigations | 346 | Zidovudine | 107 | Stavudine | 24 | Nevirapine | 24 |
| Nervous system disorders | 326 | Zidovudine | 19 | Midazolam | 15 | Ergocalciferol | 11 |
| Gastrointestinal disorders | 321 | Ibuprofen | 55 | Zidovudine | 54 | Ergocalciferol | 20 |
| Cardiac disorders | 279 | Diphemanil methylsulfate | 17 | Caffeine | 17 | Combinations of vitamins | 15 |
| Respiratory, thoracic and mediastinal disorders | 268 | Ergocalciferol | 22 | Carbocisteine | 13 | Combinations of vitamins | 11 |
| Metabolism and nutrition disorders | 224 | Zidovudine | 33 | Stavudine | 16 | Nevirapine | 16 |
| Skin and subcutaneous tissue disorders | 190 | Chlorhexidine | 9 | Amoxicillin | 9 | Cefotaxime | 9 |
| Renal and urinary disorders | 136 | Ibuprofen | 24 | Amikacin | 9 | Fentanyl | 9 |
| Vascular disorders | 96 | Midazolam | 6 | Doxapram | 6 | Labetalol | 5 |
| Musculoskeletal and connective tissue disorders | 72 | Sufentanil | 5 | Potassium clorazepate | 5 | Diazepam | 3 |
| Eye disorder | 56 | Oxytetracycline | 12 | Zidovudine | Chlorhexidine | 5 | |
| Hepatobiliary disorders | 54 | Methylthioninium chloride | 4 | Ceftriaxone | 3 | Paracetamol | 3 |
| Infections and infestations | 52 | BCG vaccine | 16 | i.v. solution additives | 6 | Amino acids IV solutions | 3 |
| Psychiatric disorders | 51 | Caffeine | 5 | Zidovudine | 4 | Phytomenadione | 3 |
Remaining SOCs account for less than 50/4106 drug‐ADR pairs