ImageStream multispectral imaging of PAM212 keratinocytes incubated with G-IsoM-siRNA (A) and G-IsoS-siRNA (B) complexes indicated colocalization of IsoM-siRNA with the nucleus. Similarity algorithm of the IDEAS software was used to measure the spatial colocalization of siRNA with the nuclei of cells where colocalization is present when a score between 1 and 2, or higher is obtained. The Mean Similarity Score for IsoM and IsoS complexes was 1.487 and 0.2983, respectively, after incubation of cells with the complexes at 37°C.
BF: Bright field; IsoM: Isonanotubes-metallic; IsoS: Isonanotubes-semiconducting.