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. 2016 Dec 5;12(12):e1006441. doi: 10.1371/journal.pgen.1006441

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© 2016 Antosova et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A-H‘) Cryosections from E10.0 control and Le-Cre;Meis1^-/-;Meis2^f/f embryos stained with antibody as indicated and nuclei counterstained with DAPI. (B, B‘) Pax6 is not detected in lens surface ectoderm of Le-Cre;Meis1^-/-;Meis2^f/f embryos (arrowheads) and (D, D‘) expression of the lens differentiation gene Foxe3 is not initiated. (F, F‘) Sox2 is detected in PLE of Meis1/Meis2 double mutants, althouth it failed to thicken. (H, H‘) Finally, expression of Six3 is decreased compared to control. Lens placode (LP) is indicated by dashed line. (A‘-H‘) For clearer examination, lens placode or corresponding lens surface ectoderm region is magnified and shown separately.