Table 3. Influence of various clinicopathological factors on expression of Gli-2 in HNSCC.

Variables	Gli-2 neg.	Gli-2 pos.	p-value*
sex
male	15 (75%)	14 (87.5%)	0.43
female	5 (25%)	2 (12.5%)
alcohol consumption
yes	15 (75%)	11 (78.6%)	0.81
no	5 (25%)	3 (21.4%)
smoking
no	3 (15%)	2 (14.3%)	0.95
yes	17 (85%)	12 (85.7%)
Age
<60 yrs	14 (70%)	8 (50%)	0.22
>60 yrs	6 (30%)	8 (50%)
pN-classification
pN0	2 (10.0%)	6 (37.5%)	0.11
pN+	18 (90%)	10 (62.5%)
staging
III	8 (40%)	4 (25%)	0.34
IV	12 (60%)	12 (75%)
chemotherapy
yes	3 (15%)	3 (18.8%)	0.76
no	17 (85%)	13 (81.3%)
tumor grading
G1	0 (0%)	1 (6.7%)	0.63
G2	19 (95%)	13 (86.7%)
G3	1 (5%)	1 (6.7%)

*p-value; a p-value ≤0.05 is considered as statistically significant

Association of sex, consumption of alcohol, history of nicotine abuse, age, rate of pathological lymph nodes, staging, chemotherapy and tumor grading with expression of Gli-2. None of the factors had a significant influence on Gli-2 expression. A p-value ≤ 0.05 was considered as statistically significant.