Table 9. Top 20 down-regulated genes after DAPT treatment in P0 Lfng-GFP+ cells.
| Rank | Gene symbol | DMSO Mean GFP+ (RPKM) | DAPT Mean GFP+ (RPKM) | Fold change DAPT vs DMSO | p-adj |
|---|---|---|---|---|---|
| 1 | Tal1 | 2983.37 | 2.56 | 0.0009 | 8.77E-181 |
| 2 | Cysltr2 | 3834.07 | 22.16 | 0.0058 | 9.07E-148 |
| 3 | Pdzk1ip1 | 2814.84 | 19.02 | 0.0068 | 5.70E-127 |
| 4 | Heyl | 4828.46 | 224.34 | 0.0464 | 1.55E-102 |
| 5 | Prss23 | 4249.27 | 215.01 | 0.0508 | 1.72E-95 |
| 6 | Gstm1 | 4572.23 | 331.06 | 0.0723 | 2.42E-80 |
| 7 | Gm10800 | 74333.61 | 8438.92 | 0.1134 | 2.45E-77 |
| 8 | 2310022B05Rik | 8186.49 | 813.73 | 0.0994 | 3.14E-74 |
| 9 | Dgat2 | 1061.61 | 21.63 | 0.0203 | 5.69E-70 |
| 10 | Syt6 | 6254.68 | 431.84 | 0.0689 | 6.15E-70 |
| 11 | Slitrk2 | 1253.99 | 38.20 | 0.0304 | 3.02E-69 |
| 12 | Ttyh1 | 13940.83 | 1688.84 | 0.1207 | 8.12E-68 |
| 13 | Pdgfrb | 2128.79 | 118.91 | 0.0559 | 2.74E-67 |
| 14 | Ccdc80 | 3066.68 | 252.98 | 0.0825 | 2.10E-66 |
| 15 | AC131780.2 | 6376.16 | 723.02 | 0.1134 | 2.31E-64 |
| 16 | Rab3b | 5451.58 | 600.43 | 0.1103 | 8.92E-64 |
| 17 | Nrarp | 1389.90 | 68.84 | 0.0494 | 2.34E-61 |
| 18 | Dkk3 | 3824.89 | 424.10 | 0.1111 | 2.32E-58 |
| 19 | Sema5a | 2652.79 | 252.04 | 0.0947 | 6.94E-56 |
| 20 | Eno1 | 3363.46 | 382.22 | 0.1134 | 3.34E-55 |
List of the 20 genes showing the greatest down-regulation in P0 Lfng-GFP+ cells after 24 hours DAPT treatment compared P0 Lfng-GFP+ cells treated with DMSO vehicle. Ranking is based on the p value. The mean expression level (RPKM) is shown, together with the fold change versus DMSO-treated cells. p-adj = adjusted p-value for the difference between DAPT and DMSO-treated populations.