Table 10. Top 20 up-regulated genes after DAPT treatment in P0 Lfng-GFP+ cells.
| Rank | Gene symbol | DMSO Mean GFP+ (RPKM) | DAPT Mean GFP+ (RPKM) | Fold change DAPT vs DMSO | p-adj |
|---|---|---|---|---|---|
| 1 | AC123795.1 | 134.87 | 18009.79 | 133.44 | 3.21E-186 |
| 2 | Scn11a | 83.16 | 6687.08 | 80.45 | 8.07E-178 |
| 3 | Ush2a | 685.76 | 26222.34 | 38.32 | 1.77E-168 |
| 4 | Fam70b | 207.23 | 7185.86 | 34.78 | 9.23E-138 |
| 5 | Vwa5b2 | 101.49 | 4564.69 | 44.94 | 7.78E-136 |
| 6 | Srrm4 | 249.11 | 6795.38 | 27.28 | 9.01E-124 |
| 7 | P2rx3 | 49.28 | 2547.23 | 51.63 | 4.06E-115 |
| 8 | Gas6 | 251.21 | 5474.75 | 21.86 | 3.31E-97 |
| 9 | Myo3a | 365.31 | 6215.50 | 17.03 | 1.57E-96 |
| 10 | Thsd7b | 457.96 | 11936.04 | 25.99 | 5.86E-95 |
| 11 | Eya2 | 33.79 | 1702.55 | 50.56 | 5.03E-94 |
| 12 | 6330503K22Rik | 1044.82 | 19337.03 | 18.51 | 4.62E-88 |
| 13 | Gadd45g | 31.74 | 1444.82 | 45.57 | 6.97E-84 |
| 14 | Mobkl2b | 307.36 | 4600.97 | 14.93 | 8.34E-84 |
| 15 | Myo7a | 348.85 | 5023.23 | 14.42 | 2.21E-83 |
| 16 | Atoh1 | 133.28 | 5021.72 | 37.79 | 2.49E-79 |
| 17 | Atp8a1 | 2348.26 | 22393.66 | 9.51 | 7.43E-79 |
| 18 | Pole | 1944.59 | 18385.23 | 9.45 | 3.89E-77 |
| 19 | Jag2 | 98.59 | 3275.67 | 33.13 | 1.01E-75 |
| 20 | Slc16a5 | 58.11 | 1531.35 | 26.35 | 1.14E-71 |
List of the 20 genes showing the greatest up-regulation in P0 Lfng-GFP+ cells after 24 hours DAPT treatment compared P0 Lfng-GFP+ cells treated with DMSO vehicle. Ranking is based on the p value. The mean expression level (RPKM) is shown, together with the fold change versus DMSO-treated cells. p-adj = adjusted p-value for the difference between DAPT and DMSO-treated populations.