Table 11. Biological processes (BP) GO terms represented in the list of transcripts down-regulated after DAPT treatment of P0 Lfng-GFP+cells that were also enriched in P1 Lfng-GFP+cells.
| Representative GO Term description (REVIGO Output) | Term ID | Included GO Term descriptions (DAVID Output) | Genes represented | log10 p value |
|---|---|---|---|---|
| Notch signaling pathway | GO:0007219 | Notch signaling pathway | Notch3, Notch1, Hey1, Heyl, Hey2, Cntn1, Jag1 | -6.4222 |
| GO:0008593 | Regulation of Notch signaling pathway | Hey2, Fgf10, Jag1 | -3.1195 | |
| GO:0016055 | Wnt signaling pathway | Fzd9, Sfrp1, Frzb, Fzd4, Wnt7a | -2.3026 | |
| Cell fate commitment | GO:0045165 | Cell fate commitment | Notch3, Tal1, Notch1, Erbb4, Hes5, Fgf10, Sox6, Tgfb2 | -4.91 |
| GO:0048729 | Tissue morphogenesis | Notch1, Sfrp1, Fgf10, Sema3a, Nr4a3, Jag1, Wnt7a, Tgfb2 | -3.5865 | |
| GO:0051094 | Positive regulation of developmental process | Tal1, Notch1, Hey2, Jag1, Igfbp3, Wnt7a, Tgfb2 | -3.0288 | |
| Cell adhesion | GO:0007155 | Cell adhesion | Egfl6, Fblim1, Tgfb2, Cd9, Pgm5, Itga6, Hes5, Fat3, Lsamp, Ttyh1, Cntn1, Lamc2, Thbs1 | -4.4589 |
| Cell projection organization | GO:0030030 | Cell projection organization | Notch1, Itga6, Ptprz1, Ttyh1, Sema3a, Slitrk6, Tgfb2 | -2.1669 |
Summary of biological processes GO terms that were significantly represented (p<0.01) in 97 genes enriched in P1 LfngGFP+ cells (filtered list: present in both DESeq and Cufflinks outputs, RPKM>3000, FC>4) and down regulated in P0 LfngGFP+ DAPT 24 hours treated cells (present in DESeq or Cufflinks outputs and FC>2) relative to their DMSO treated counterparts. The biological processes represented were obtained with the DAVID bioinformatics suite and then summarized with the REVIGO tool.