Table 1. . Overview of cell line characteristics and interaction between hypoxia, AKT and hypoxia inducible factor 1 signaling.
| Cell line | Tumor type | Histology type | Hypoxic induction of pAKT | Downregulation of HIF-1 signaling by AKT inhibition | Enhanced sensitivity to AKT inhibition under hypoxia |
|---|---|---|---|---|---|
| UT-SCC5 |
HNSCC |
Squamous cell |
++ |
- |
++ |
| UT-SCC15 |
HNSCC |
Squamous cell |
++ |
++ |
++ |
| UT-SCC24A |
HNSCC |
Squamous cell |
- |
++ |
-/+ |
| UT-SCC38 |
HNSCC |
Squamous cell |
++ |
- |
- |
| H226 |
NSCLC |
Squamous cell |
+ |
+ |
++ |
| SW900 |
NSCLC |
Squamous cell |
+ |
- |
++ |
| H520 |
NSCLC |
Squamous cell |
- |
- |
- |
| H522 |
NSCLC |
Adenocarcinoma |
+ |
- |
- |
| HCC827 |
NSCLC |
Adenocarcinoma |
- |
- |
- |
| H1975 | NSCLC | Adenocarcinoma | - | - | + |
++: Strongly present; +: Present ; -/+: Marginal; -: Negative; HIF-1: Hypoxia inducible factor 1; HNSCC: Head and neck squamous cell carcinoma; NSCLC: Non-small-cell lung cancer; pAKT: Phosphorylation of AKT.