Figure 9. . Evaluation of potential toxicity of zerumbone-loaded nanostructured lipid carriers in BALB/c mice model through histopathology of tissues.
(A) Liver, (B) kidney and (C) lung histograms of female BALB/c mice treated orally, with (a) water (control), (b) olive oil (vehicle), (c & d) zerumbone at concentrations 100 and 200 mg/kg, (e & f) blank nanostructured lipid carriers at concentrations 100 and 200 mg/kg and (g & h) zerumbone-loaded nanostructured lipid carriers at concentrations 100 and 200 mg/kg for 14 days. No sign of toxicity was observed in the organs of these mice (400 × magnification).
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