Table 4. . Nanostructured lipid carriers fabricated using solvent diffusion technique.

Active ingredient	Solid lipid	Liquid lipid	Surfactants	Size (nm)	Research highlights	Ref.
β-carotene	Palmitic acid	Corn oil	Tween 20	8–15	Decreased β-carotene degradation was achieved	[41]
Docetaxel oleate	Glyceryl monostearate	Oleic acid	Poloxamer F68	100	Prodrug of docetaxel, in other words, docetaxel oleate was successfully loaded with high loading efficiency NLCs showed 2.06-fold higher bioavailability in comparison to drug suspension	[42]
Isoliquiritigenin	Glycerol monostearate	Miglyol® 812	Tween 80, poloxamer 188	NA	Significant improvement in AUC values in orally administered drug-loaded NLCs in comparison to oral solution of drug	[43]
Raloxifene hydrochloride	Glyceryl monostearate	Capmul MCM C8	Polyvinyl alcohol	32.50 ± 5.12	3.75-fold significant improvement in bioavailability of poorly soluble drug than plain drug suspension, which bestow its potential role as suitable carrier system for oral delivery in the treatment of osteoporosis	[44]
Tamoxifen citrate	Glyceryl monostearate	Labrafil WL 2609 BL	Tween 20, Tween 80, poloxamer 188	215.60 ± 7.8	Improved pharmacokinetic parameters of drug-loaded NLCs in comparison to drug suspension Improved anticancer efficacy	[45]
Tamoxifen citrate	Glyceryl monostearate	Labrafil WL 2609 BL	Tween 20, Tween 80, poloxamer 188	215.60 ± 7.8	NLCs were able to withstand various GIT media Sustained release was obtained irrespective of pH of media	[46]

AUC: Area under curve; GIT: GI tract; NA: Not available; NLC: Nanostructured lipid carrier.