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. 2016 Dec 1;10:3933–3946. doi: 10.2147/DDDT.S116286

Figure 10.

Figure 10

Effect of CMCNa, MSNS, 6MP plus CDDP and MSNS-6MP/CDDP on the left kidney histology.

Notes: (A) Left kidney histology of S180 mice treated by CMCNa; (B) left kidney histology of S180 mice treated by MSNS (50 mg·kg−1·day−1); (C) left kidney histology of S180 mice treated by 6MP (1 mg·kg−1·day−1) plus CDDP (5 mg·kg−1·day−1), and the area labelled by yellow circles show damage to the tubular epithelium, the formation of intratubular cast and tubular dilatation; (D) left kidney histology of S180 mice treated by MSNS-6MP/CDDP (50 mg·kg−1·day−1, corresponding to 1 mg·kg−1·day−1 of 6MP and 5 mg·kg−1·day−1 of CDDP); H&E stain, original magnification 40×, n=5.

Abbreviations: CMCNa, sodium carboxyl methyl cellulose; MSNS, SH surfaced mesoporous silica nanoparticles; 6MP, 6-mercaptopurine; CDDP, cisplatin; MSNS-6MP, 6MP covalently modified MSNS; MSNS-6MP/CDDP, CDDP-loaded MSNS-6MP; H&E, hematoxylin and eosin.