Fig 5. Inhibition of the ATM DNA damage pathway in CXCR4¹⁰¹³-expressing rafts.

Western blots and densitometric analyses showing relative levels of involucrin and p53 (A), HPV18-E6 (B), pATM, ATM, pCHK2 and CHK2 (C) in HPV18-positive CXCR4^wt and CXCR4¹⁰¹³ NIKS cells differentiated in high calcium media (Ca) for indicated times. Levels of target proteins were normalized to GAPDH protein levels and arbitrarily set at 1 for undifferentiated (Ca 0 h) CXCR4^wt NIKS cells. Values are means ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001.