Table 1.

Summary of 6 KLAL Patients with Late Acute Graft Rejection

Case No.	Eye	Age* (yrs)	Sex	Diagnosis	Follow-up Period Interventions	Time to Rejection (months)	SLE Findings	SI at Time of Rejection**	Medical Treatment of Rejection**	Outcome
1	OS	43	M	Chemical injury	BCL, OHTN drops	59.3	Inferior NV, ERL	MMF 250 mg BID	DFP 0.05% gtt Q1H, MMF 750 mg BID	Partial failure
2	OS	26	M	Anirida	CE + IOL with tube	98.4	Superior ERL	Azathioprine 100 mg, Prednisone 15 mg	DFP 0.05% gtt Q1H, Tacrolimus 3 mg BID, MMF 1000 mg BID, Prednisone 7 mg	Partial failure
3	OD	52	M	Chemical injury	Repeat PK x2	94.3	360° ERL, edema	None	Prednisolone acetate gtt Q1H	Total failure
4	OS	22	M	Chemical injury	OHTN drops	49.0	Superior CZN, ERL, CEI	MMF 500 mg, Tacrolimus 1 mg	Prednisolone 1 mg/kg, Betamethasone (high frequency)	Resolved with residual CEI
5	OS	38	M	Chemical injury	Tarsorrhaphy	70.0	Superior ERL, edema, CEI, CED	MMF 500 mg Tacrolimus 1 mg	Prednisolone 1 mg/kg, Betamethasone (high frequency)	Resolved with residual CEI
6	OD	37	F	Aniridia	OHTN drops, Diode CPC	67.0	ERL	None	Prednisolone acetate gtt Q2H, MMF 500 mg BID	Partial failure

KLAL = Kerato-limbal allograft; SLE = slit lamp examination; SI = systemic immunosuppression; BCL = bandage contact lens; OHTN = ocular hypertension; NV = neovascularization; ERL = epithelial rejection line; MMF = Mycophenolate Mofetil; DFP = difluprednate; PK = penetrating keratoplasty; CZN = conjunctivalization; CEI = corneal epithelial irregularity; CED = corneal epithelial defect; CPC = cyclophotocoagulation

^*At time of KLAL procedure.

^**All medications were oral (PO) and daily (QD) unless otherwise specified.