Table 1. Relative density of UBE3A staining in AS and KO mice, compared to WT.

The analysis was performed on large EM photomontages of neuropil (each ~ 10 × 10 µm, 15 fields per mouse, 3 mice per group) and on montages of entire neuronal nuclei (15 nuclei per mouse, 3 mice per group) from the CA1 region of the hippocampus and from layer II-III of the primary visual cortex. Data (expressed as percent of label in WT mice) are means ± SEM from three independent experiments.

	Adult				P7
	Neocortex		Hippocampus		Neocortex		Hippocampus
	Nuclei	Neuropil	Nuclei	Neuropil	Nuclei	Neuropil	Nuclei	Neuropil
AS	8.6% ± 2.3	20% ± 3.3	2.2% ± 0.8	28% ± 2.7	9.5% ± 2.3	32% ± 1.3	5.1% ± 1.6	27% ± 0.5
KO	1.6% ± 0.2	8.1% ± 0.1	4.1% ± 0.1	6.9% ± 0.3	4.2% ± 2.1	6.5% ± 2.2	2.2% ± 1.0	6.8% ± 0.4