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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Curr Opin Biotechnol. 2016 Aug 6;42:189–197. doi: 10.1016/j.copbio.2016.07.005

Figure 1. Representative AdoMet utilization and degradation pathways.

Figure 1

(a) AdoMet serves as a critical alkyl donor in most MT-catalyzed reactions within the context of modifying nucleic acids, proteins and small molecule-based metabolites (blue sphere signifies methyl in native systems). (b) AdoMet chemically degrades via intramolecular cyclization (pathway i) and depurination (pathway ii).