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. Author manuscript; available in PMC: 2018 Jan 15.
Published in final edited form as: Stat Med. 2016 Sep 15;36(1):67–80. doi: 10.1002/sim.7134

Table 1.

Toxicities and Severity Weights in the Example

Toxicity Type Grade Severity Weight DLT
Renal 1 0.5 No
2 0.75 No
3 1 Yes
4 1.5 Yes
Neurological 1 0.5 No
2 0.75 No
3 1 Yes
4 1.5 Yes
Hematological 3 0.5 No
4 1 Yes