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Impact of timing of anti-angiogenic drug delivery relative to paclitaxel treatment on HCT-116 tumors growth. SCIDasmase+/+ mice harboring tumors were handled as in Figure 5A. DC101 (1.6 mg per mouse i.v.) was provided either before (A) or after (B) paclitaxel treatment. Mice harboring tumors were treated with paclitaxel (15/15/15 mg/kg i.p) three times biweekly. Data (mean±SD) were collated from 5 mice/group.
