Table 2.
Association of MTHFR C677T with breast cancer risk across different studies
| Author | MTHFR 677 T-allele frequency | OR | 95 % CI | ||
|---|---|---|---|---|---|
| Cases | Controls | Limit | Limit | ||
| Kalyan | 0.5698 | 0.4536 | 1.5892 | 0.9785 | 2.581 |
| Mir | 0.2727 | 0.5614 | 0.3084 | 0.1158 | 0.8214 |
| Naushad | 0.6139 | 0.4869 | 1.6676 | 1.0959 | 2.5376 |
| Prasad | 0.4118 | 0.5132 | 0.6777 | 0.2612 | 1.7584 |
| Barbosa | 0.4906 | 0.52 | 0.8894 | 0.6482 | 1.2205 |
| Ma | 0.4938 | 0.5028 | 0.9648 | 0.7912 | 1.1765 |
| Xu | 0.5105 | 0.478 | 1.1386 | 1.0075 | 1.2868 |
| Bentley | 0.439 | 0.43 | 1.0371 | 0.918 | 1.1717 |
| Platek | 0.3568 | 0.3548 | 1.0088 | 0.899 | 1.1321 |
| Tao | 0.2191 | 0.2218 | 0.9847 | 0.8519 | 1.1381 |
| Chen | 0.5105 | 0.478 | 1.1386 | 1.0075 | 1.2868 |
| Maruti | 0.3615 | 0.3137 | 1.2389 | 1.0148 | 1.5125 |
| Jin | 0.2989 | 0.2872 | 1.0639 | 0.6136 | 1.8447 |
| Yu | 0.2199 | 0.201 | 1.1238 | 0.8071 | 1.5649 |
| Liu | 0.5082 | 0.4973 | 1.0443 | 0.8396 | 1.2989 |
| Cheng | 0.3916 | 0.3992 | 0.9691 | 0.7839 | 1.1981 |
| Gao | 0.5305 | 0.4791 | 1.2286 | 1.0471 | 1.4416 |
| Wu | 0.4348 | 0.4696 | 0.8777 | 0.3622 | 2.1267 |
| Weiwei | 0.5539 | 0.469 | 1.4044 | 1.0904 | 1.809 |
| Jiang-Hua | 0.5063 | 0.4127 | 1.4595 | 1.2301 | 1.7315 |
| He | 0.5 | 0.427 | 1.3418 | 1.0646 | 1.691 |
| Wu | 0.6039 | 0.4036 | 2.2411 | 1.4345 | 3.5013 |
| Li | 0.3978 | 0.2879 | 1.6362 | 1.0148 | 2.6381 |
| Yuan | 0.6039 | 0.4036 | 2.2411 | 1.4345 | 3.5013 |
| Qi | 0.5359 | 0.4574 | 1.3689 | 1.0484 | 1.7874 |
| Shrubsole | 0.4873 | 0.491 | 0.9855 | 0.8758 | 1.1089 |
| Kan | 0.6083 | 0.5268 | 1.3905 | 0.9109 | 2.1224 |
| Hua | 0.4432 | 0.5355 | 0.6926 | 0.429 | 1.1182 |
| Lin | 0.2122 | 0.2016 | 1.0711 | 0.7451 | 1.5397 |
| Chou | 0.3187 | 0.3391 | 0.9134 | 0.6723 | 1.241 |
| Yu | 0.2466 | 0.2112 | 1.2253 | 0.8936 | 1.6802 |
| Justenhoven | 0.4599 | 0.4908 | 0.8837 | 0.7482 | 1.0438 |
| Reljic | 0.5962 | 0.5849 | 1.0454 | 0.6498 | 1.6818 |
| kalemi | 0.4545 | 0.45 | 1.0196 | 0.5598 | 1.857 |
| Deligezer | 0.5158 | 0.4378 | 1.3671 | 1.0043 | 1.861 |
| Ozen | 0.4828 | 0.2891 | 2.289 | 1.285 | 4.0775 |
| Ergul | 0.4032 | 0.3693 | 1.1551 | 0.8133 | 1.6405 |
| Hekim | 0.3704 | 0.3704 | 1.0067 | 0.535 | 1.8944 |
| Cam | 0.5814 | 0.516 | 1.2996 | 0.8544 | 1.9768 |
| Akram | 0.5 | 0.5 | 1 | 0.6648 | 1.5042 |
| Grieu | 0.352 | 0.389 | 0.8539 | 0.693 | 1.0522 |
| Campbell | 0.623 | 0.574 | 1.2248 | 0.9493 | 1.5802 |
| Beetstra | 0.56 | 0.4211 | 1.724 | 0.6782 | 4.3826 |
| Awward | 0.544 | 0.4902 | 1.2389 | 0.8737 | 1.7569 |
| Lee | 0.5839 | 0.5408 | 1.1907 | 0.8722 | 1.6253 |
| Le Marchand | 0.3965 | 0.4628 | 0.7632 | 0.6165 | 0.9447 |
| Inoue | 0.3418 | 0.3714 | 0.8797 | 0.7096 | 1.0905 |
| Suzuki | 0.3511 | 0.3208 | 1.1459 | 0.9749 | 1.3468 |
| Alshatwi | 0.5093 | 0.4937 | 1.064 | 0.7142 | 1.5852 |
| Sangrajrang | 0.551 | 0.5338 | 1.0713 | 0.8365 | 1.3719 |
| Hosseini | 0.4444 | 0.5185 | 0.7434 | 0.5818 | 0.9497 |
| Lajin | 0.5698 | 0.4403 | 1.6797 | 1.1563 | 2.4401 |
| Liu | 0.5364 | 0.4755 | 1.276 | 1.0532 | 1.5459 |
| Diakite | 0.5339 | 0.4188 | 1.5859 | 1.0366 | 2.4262 |
| Batschauer | 0.4272 | 0.48 | 0.8084 | 0.5014 | 1.3035 |
| Cortes | 0.4256 | 0.3324 | 1.4868 | 1.0663 | 2.0732 |
| Silva | 0.6531 | 0.5627 | 1.4613 | 1.1872 | 1.7988 |
| Maria | 0.4947 | 0.4698 | 1.1049 | 0.98 | 1.2456 |
| Ericson | 0.3571 | 0.3232 | 1.1642 | 0.9422 | 1.4384 |
| [Combined] | |||||
| Fixed | 1.1031 | 1.0707 | 1.1364 | ||
| Random | 1.1333 | 1.0734 | 1.1966 | ||