Table 1.
Comparison of particle size, PDI and EE of Rho-loaded PLGA NPs prepared by varying different parameters.
| Sonication time (min) | Mean diameter (nm) | PDI | EE (% ± SD) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Influence of sonication time | |||||||||
| 3 | 204 ± 12 | 0.18 ± 0.01 | 17 ± 10.41 | ||||||
| 5 | 190 ± 12 | 0.19 ± 0.03 | 25 ± 12.01 | ||||||
| 10 | 184 ± 7 | 0.19 ± 0.01 | 40 ± 2.94 | ||||||
| PVA content (% w/v) | Mean diameter (nm) | PDI | EE (% ± SD) | ||||||
| Influence of PVA content | |||||||||
| 0.5 | 229 ± 17 | 0.22 ± 0.03 | 72 ± 4.58 | ||||||
| 1 | 222 ± 5 | 0.23 ± 0.02 | 65.5 ± 1.91 | ||||||
| 2.5 | 184 ± 7 | 0.19 ± 0.01 | 40 ± 2.94 | ||||||
| org/aq | Mean diameter (nm) | PDI | EE (% ± SD) | ||||||
| Influence of organic to aqueous phase volume | |||||||||
| 0.5:10 | 232 ± 12 | 0.24 ± 0.01 | 50.25 ± 1.71 | ||||||
| 1:10 | 184 ± 7 | 0.19 ± 0.01 | 40 ± 2.94 | ||||||
| 2:10 | 195 ± 7 | 0.23 ± 0.01 | 34.5 ± 2.52 | ||||||
PDI, polydispersity index; EE, encapsulation efficiency. Values are presented as mean ± standard deviation, n = 3.