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. 2016 Dec 6;9:141. doi: 10.3389/fnmol.2016.00141

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Copyright © 2016 Qi, Liu, Weng, Xu, Chen, Wang, Zhang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Group comparison of interhemispheric functional connectivity between IBS patients and HCs. Results of a two-sample t-test of VMHC reveal lower VMHC in vACC and IPL, while higher VMHC in thalamus, cuneus, PCC, lingual gyrus and inferior occipital/cerebellum lobes in IBS patients relative to HCs. Inclusion of anxiety and depression as covariates eliminated the VMHC difference in the vACC between two groups. IBS, irritable bowel syndrome; VMHC, voxel-mirrored homotopic connectivity; vACC, ventral anterior cingulate cortex; IPL, inferior parietal lobule; PCC, posterior cingulate cortex.