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. 2016 Dec 6;6:177. doi: 10.3389/fcimb.2016.00177

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Copyright © 2016 Liu, Lu, Orfe, Ren, Hu, Call, Avillan and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ExsE is a negative regulator for T3SS genes transcription in V. alginolyticus. 10 T3SS genes, including structural genes (vscY and vseE), effector genes (1687 and 1686), translocation genes (vopB and vopD) and regulatory genes (exsA, exsC, exsD and exsE), were examined using qPCR to show their transcription pattern in different V. alginolyticus strains (ZJO, ΔexsE and ΔexsE:pexsE) in TSB or contact with FHM cells. T3SS genes were transcribed after contact with host cells while transcription is limited under TSB only conditions. Deletion of exsE resulted in significantly more T3SS transcription under non-inducing conditions and transcription was inhibited by overexpression of exsE in wild-type strain even under inducing conditions. Average normalized expression data were added into individual box in the heatmap.