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. 2016 Dec 6;7:1925. doi: 10.3389/fmicb.2016.01925

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Copyright © 2016 Liu, Wang, Yu, Li, Liu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An overview of potential antifungal targets against a Candida biofilm based on an enzyme in the arachidonic acid cascade. Gene (green); enzyme (pink); metabolites (blue); inhibitors (yellow); Question mark: PG E2 can regulate biofilm morphogenesis, biofilm formation and biofilm adherence, whether PGE2 modulates biofilm formation of C. albicans by regulating these genes is uncertain; cPLA2a, cytosolic PLA2a; CYP, cytochrome P450; LOX, lipoxygenase; COX, cyclooxygenase; mPGES, microsomal; prostaglandin E2 synthase; NSAIDS, Non-Steroidal Antiinflammatory Drugs; PGG2, prostaglandin G2; PGH2, prostaglandin H2; PGE2, prostaglandin E2; NO, nitric oxide.