Table 1A.
Subject | Gender | Age at surgery (year) | Disease duration at surgery (year) | LEDD pre-DBS (mg) | UPDRS pre-DBS meds-off (score) | UPDRS pre-DBS meds-on (score) | LEDD post-DBS (mg) | UPDRS post-DBS meds-off, stim-on (score) |
---|---|---|---|---|---|---|---|---|
wue2* | male | 65 | 10 | 1100 | 40 | 23 | 800 | 19 |
wue3 | male | 61 | 18 | 2725 | 40 | 9 | 600 | 13 |
wue5* | male | 67 | 17 | 1050 | 49 | 24 | 500 | 13 |
wue6 | male | 51 | 11 | 1133 | 47 | 12 | 180 | 9 |
wue7 | male | 61 | 10 | 650 | 43 | 24 | 220 | 19 |
wue9* | male | 55 | 19 | 1200 | 50 | 11 | 730 | 16 |
wue11* | female | 53 | 11 | 1300 | 55 | 4 | 460 | 9 |
Demographic and clinical information. Before surgery participants were tested after overnight withdrawal of all dopaminergic medications (meds-off). To evaluate the effect of levodopa (meds-on), the patient had turned into a good quality “on-state” upon receiving 1–1.5-times the levodopa-equivalent of the preoperative morning dose. After surgery, all patients were evaluated in meds-off condition but under chronically effective STN stimulation (meds-off, stim-on). *Indicates the four patients (i.e., wue2, 5, 9 and 11) who were able to complete the motor task (i.e., with both hands in the required amount of time, please refer to “Task and Experimental Design” in the “Materials and Methods Section”). DBS, deep brain stimulation; LEDD, levodopa equivalent daily dose; STN, subthalamic nucleus; UPDRS-III, Unified Parkinson Disease Rating Scale motor part.