Table 1.

Conditions with increased risk of infertility

Risk of infertility	Males	Females
High risk (>80% risk of permanent amenorrhea in women; prolonged azoospermia in men)	Radiation  >2.5 Gy to testis Chlorambucil (1.4 g/m2) Cyclophosphamide (19 g/m2) Procarbazine (4 g/m2) Melphalan (140 mg/m2) Cisplatin (500 mg/m2) BCNU (1 g/m2) and CCNU (500 mg/m2)	Hematopoietic stem cell transplantation with cyclophosphamide Total-body irradiation or cyclophosphamide/busulfan External beam radiation to a field that includes the ovaries CMF, CEF, CAF, TAC × 6 cycles in women ≥40 years
Intermediate risk (40– 60% risk of permanent amenorrhea in women; likelihood of azoospermia in men)	Busulfan (600 mg/kg) Ifosfamide (42 g/m2) BCNU (300 mg/m2) Nitrogen mustard Actinomycin D	BEACOPP CMF, CEF, CAF, TAC × 6 cycles in women age 30–39 AC × 4 cycles in women ≥40 years AC or EC × 4 → Taxanes

AC adriamycin, cyclophosphamide, BEACOPP Bleomycin, Etoposide , Adriamycin, Cyclophosphamide, Vincristine, Procarbazine, Prednisona, CAF Cyclophosphamide , Adriamycin, 5-fluoruracil, CEF Cyclophosphamide, Epirrubicin, 5-fluoruracil, CMF cyclophosphamide, Methotrexate, 5-fluoruracil, TAC Docetaxel, Adriamycin, Cyclophosphamide