Table 3.

Options to fertility-sparing interventions in female patients undergoing surgery

Type of tumor	Surgery	Oncologic outcomes	Obstetric outcomes
Borderline ovarian tumors FIGO stage I	Unilateral oophorectomy	Oncologic outcome is comparable with the more radical approach of removing both ovaries and the uterus Recurrence 0–20 versus 12–58% when only cystectomy was performed	Pregnancies have been reported with a favorable obstetric outcome
Ovarian epithelial cancer stage I, grade 1	Unilateral oophorectomy	7% recurrence of the ovarian malignancy and 5% deaths	Pregnancies have been reported with a favorable obstetric outcome
Malignant ovarian germ cell tumors/sex cord stromal tumors	Unilateral oophorectomy	Risk of recurrence similar to historical controls	Pregnancies have been reported and favorable obstetric outcome
Cervical cancer stage IA1, 1A2, 1B1	Radical vaginal trachelectomy	Rates of recurrence and mortality are comparable with those described for similar cases treated by radical hysterectomy or radiation therapy	Spontaneous pregnancies described in up to 70%. Risk of second-trimester pregnancy loss and preterm delivery
Endometrial adenocarcinoma grade 1, stage 1A (without myometrial or cervical invasion)	Hormonal treatment with progestational agents for 6 months	Recurrence rate 30–40%; 5% recurrence during progesterone treatment	Pregnancies have been reported

Modified from Rodriguez-Wallberg et al. [7]