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. 2016 Oct 11;67(1):83–95. doi: 10.1007/s12576-016-0495-7

Fig. 4.

Fig. 4

Representative DREADD receptors and their effects in hypothalamic AgRP neurons. Gq-, Gs-, and Gi-type DREADDs can stimulate different signaling pathways following CNO administration. Use of DREADDs makes it possible to investigate the precise functions of specific neuronal cell types in vivo (e.g., the relationship between signaling pathways in AgRP neurons and food intake)