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. 2016 Oct 11;67(1):83–95. doi: 10.1007/s12576-016-0495-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Different roles of G_q- and G_s-coupled GPCRs expressed by AgRP neurons in food intake. G_q-coupled GPCRs (e.g., ghrelin receptors) stimulate the calcium signaling pathway, resulting in an acute feeding response caused by NPY and GABA release. By contrast, G_s-coupled GPCRs (e.g., PACAP receptors) stimulate the cAMP signaling pathway, resulting in long-lasting feeding caused by AgRP release