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. 2016 Oct 11;67(1):83–95. doi: 10.1007/s12576-016-0495-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — A schematic model for the relationships between NMDA-R, d-serine, and appetite. Alteration in the local d-serine concentration or sensitivity to d-serine in the neurocircuitry for feeding may affect the feeding behavior. Excessive facilitation of glutamatergic inputs through NMDA receptors by increased local d-serine concentration leads to decreases in the intake and the preference for food. Conversely, decreased local d-serine concentration may lead to increases in the intake and the preference for food