Table 1.
Cumulative listing of predicted GPCRs and proteins related to the GPCR signaling cascade from the Texas cattle tick synganglion transcriptome.
| Predicted protein name | Candidate Unigene IDsa |
|---|---|
| GPCR Rhodopsin family | |
| 5-Hydroxytryptamine receptor | MTc32715 |
| 5-Hydroxytryptamine type 7 receptor |
MTc22509 |
| Acetylcholine receptor, G-protein-linked |
MTc5003 |
| Acetylcholine receptor gar-2A, G-protein-linked |
MTc22266 |
| Acetylcholine receptor, Muscarinic | MTc2211, MTc40499 |
| Allatostatin receptor | MTc6228 |
| Allatostatin-A receptor | MTc39630 |
| Capa receptor | MTc21993 |
| Dopamine D1/beta receptor | MTc1524 |
| Dopamine type 2 receptor | MTc15956, MTc24736 |
| Leucine-rich repeat-containing G-protein coupled receptor |
MTc20805 |
| Leucine-rich repeat-containing G-protein coupled receptor 5 |
MTc25248 |
| Myoinhibitory peptide receptor | MTc27624 |
| Neuropeptide FF receptor | MTc27095 |
| Neuropeptide receptor 15 | MTc21990 |
| Neuropeptide receptor A31 | MTc35823 |
| Neuropeptide Y receptor | MTc10061, MTc41765 |
| Octopamine receptor, Alpha 2 adrenergic-like |
MTc34982 |
| Octopamine receptor |
MTc1903, MTc3394, MTc5330, MTc24553, MTc28003, MTc41218 |
| Pyrokinin receptor | MTc15995, MTc24861 |
| Pyrokinin-like receptor | MTc104 |
| Relaxin receptor 2 | MTc37046 |
| Serotonin receptor | MTc4134, MTc4625, MTc22214 |
| Substance-K receptor | MTc8234, MTc29471 |
| Sulfakinin receptor | MTc8208 |
| Vesicular amine transporter | MTc422 |
| Predicted Rhodopsin family but no candidate identity |
MTc287, MTc925, MTc1475, MTc3264, MTc3696, MTc4791, MTc5115, MTc5617, MTc5741, MTc6796, MTc7698, MTc7846, MTc8067, MTc9908, MTc11315, MTc14173, MTc14673, MTc15391, MTc15557, MTc16269, MTc17406, MTc17511, MTc21160, MTc21447, MTc22106, MTc22868, MTc24520, MTc25152, MTc27818, MTc32073, MTc32084, MTc32224, MTc35522, MTc35757, MTc39286, MTc40170, MTc41195, MTc42769, MTc43929 |
| GPCR Secretin family | |
| Calcitonin receptor | MTc5685, MTc19512, MTc39975 |
| Corticotropin-releasing factor receptor type |
MTc20694, MTc25752 |
| DH31 receptor | MTc20395 |
| Latrophilin | MTc14709, MTc25802, MTc44419 |
| Methuselah-like 3 | MTc1232 |
| Parathyroid hormone/parathyroid hormone-related peptide receptor |
MTc17148 |
| Predicted Secretin Family but no Candidate Identity |
MTc19630, MTc20723, MTc32602, MTc39823, MTc39868, MTc40313, MTc42573 |
| GPCR glutamate family | |
| Metabotropic GABA-B receptor subtype |
MTc42297 |
| Metabotropic gamma-aminobutyric acid receptor |
MTc840, MTc2654, MTc39275, MTc43975 |
| Metabotropic glutamate receptor | MTc17814 |
| Metabotropic glutamate receptor 1 | MTc1831, MTc37251 |
| metabotropic glutamate receptor 2 | MTc7139 |
| Metabotropic glutamate receptor 4, 6, 7 |
MTc44180 |
| Pheromone and odorant receptor | MTc20045, MTc21997, MTc22950, MTc23544 |
| Predicted Glutamate Family but no Candidate Identity |
MTc12 |
| GPCR predicted but unclassifiable to family |
|
| MTc37686 | |
| MTc27554 | |
| G proteins | |
| Guanine nucleotide binding protein beta subunit |
MTc8797, MTc3426, MTc10031, MTc10239, MTc10469, MTc10616, MTc10744, MTc11060, MTc12068, MTc13386, MTc14081, MTc14129, MTc14435, MTc14489, MTc15183, MTc18040, MTc24941, MTc26235, MTc26826, MTc29590, MTc31138, MTc31358, MTc34616, MTc37393, MTc37592, MTc39119, MTc40432, MTc41893, MTc42759, MTc44290 |
| G protein beta subunit-like protein | MTc31519, MTc31755, MTc39402 |
| GTP-binding protein (Q) alpha-11 subunit, gna11 |
MTc6574 |
| GTP-binding protein (I) alpha subunit, gnai |
MTc43652 |
| Guanine nucleotide-binding protein G(O) subunit alpha |
MTc896 |
| Guanine nucleotide-binding protein subunit gamma |
MTc9439, MTc25067 |
| G protein-coupled receptor kinase | |
| G-protein coupled receptor kinase 2/3 |
MTc18044 |
| Adenylyl cyclase | |
| Adenylyl cyclase | MTc1356, MTc17511, MTc19476, MTc21334, MTc27478, MTc27533, MTc31965, MTc33919, MTc34460, MTc36772, MTc36830, MTc38293, MTc39594, MTc41584, MTc41766 |
| Adenylyl cyclase type | MTc6353, MTc17129 |
| Adenylyl cyclase type 2 | MTc3632 |
| Adenylyl cyclase-associated protein | MTc2672, MTc6656, MTc7841 |
| Inositol triphosphate receptor | |
| Type 3 inositol 1,4,5-trisphosphate receptor |
MTc21140, MTc37353 |
| Arrestin | |
| Arrestin domain-containing protein | MTc297, MTc18392 |
| Beta-arrestin 1 | MTc6527 |
a
See Supplemental files for detailed information about each contig. The 22 Texas tick contigs in bold text were noted in the initial BLASTX search of the Uniref100 database (Supplemental file 4) with top hit description term of “G-protein coupled receptor”.