Table 4.
Logistic regression analysis for significant emphysematous change (LAA ≥ 8.0).
| Cathepsin S and LAA ≥ 8.0 | Cat S/Cys C (/103) and LAA ≥ 8.0 | |||||||
|---|---|---|---|---|---|---|---|---|
| χ 2 | p | OR | 95% CI | χ 2 | p | OR | 95% CI | |
| Cat S (10 increments) | 12.21 | 0.001∗∗ | 0.28 | 0.14–0.57 | — | — | — | — |
| Cat S/Cys C (/103) | — | — | — | — | 9.83 | 0.002∗∗ | 0.82 | 0.72–0.93 |
| Age (10 increments) | 5.72 | 0.02∗ | 2.08 | 1.14–3.78 | 3.76 | 0.052 | 1.72 | 0.99–2.98 |
| BMI | 3.45 | 0.06 | 0.87 | 0.75–1.01 | 4.36 | 0.04∗ | 0.85 | 0.73–0.99 |
| PY (10 increments) | 1.92 | 0.17 | 1.09 | 0.96–1.24 | 0.74 | 0.39 | 1.05 | 0.94–1.19 |
| Serum Cr | 0.37 | 0.54 | 0.40 | 0.02–7.71 | 1.55 | 0.21 | 0.16 | 0.009–2.88 |
| Male | 1.28 | 0.26 | 3.17 | 0.43–23.4 | 2.51 | 0.11 | 4.71 | 0.69–32.1 |
| Ex-smoker | 0.31 | 0.58 | 1.30 | 0.51–3.29 | 1.46 | 0.23 | 1.76 | 0.70–4.42 |
| HT (−) | 0.84 | 0.36 | 0.58 | 0.18–1.86 | 0.77 | 0.38 | 0.60 | 0.20–1.87 |
| ICS (−) | 0.07 | 0.79 | 0.85 | 0.25–2.89 | 0.21 | 0.65 | 0.76 | 0.23–2.51 |
∗ p < 0.05; ∗∗ p < 0.01. LAA: low attenuation area; Cat: cathepsin; Cys: cystatin; OR: odds ratio; CI: confidence interval; BMI: body mass index; PY: pack-years; Cr: creatinine; HT: hypertension; ICS: inhaled corticosteroid.