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. 2016 Dec 6;6:38385. doi: 10.1038/srep38385

Table 3. Proteomic and transcriptomic changes of the spots that changed significantly in the proteomic analysis of CMA-treated HeLa cells.

Protein name GENE   Proteomic changes
 Transcriptomic changes
 Remarks
Spot no CMA   Dp44mT     CMA Dp44mT
Adenylyl cyclase-associated protein 1 CAP1   1137 0.54 *** 0.76 **   1.05 1.34  
Annexin A1 ANXA1   1491 1.14 ** 1.12 **   2.88 2.77  
ATP-dependent RNA helicase DDX3X DDX3X   2064 1.23 ** 1.20 **   0.97 1.06  
Cytoplasmic aconitate hydratase ACO1   662 1.32 *** 1.09     1.21 0.99 Iron
Dihydropyrimidinase-related protein 3 DPYSL3   890 1.48 ** 1.12     0.91 0.92  
DNA polymerase subunit delta 2 POLD2   1237 1.25 ** 1.08     0.74 0.70  
Elongation factor 1-beta EEF1B2   2039 0.85 * 0.98     0.90 0.94  
Elongation factor 1-delta EEF1D   1556 1.20 *** 1.19 ***   0.99 0.99  
Elongation factor 2 EEF2   643 1.87 *** 1.12     1.05 1.00  
      657 0.75 ** 0.53 ***        
Fructose-bisphosphate aldolase A ALDOA   2091 1.44 *** 1.28 **   1.78 1.52 Glycolysis
      2132 1.27 *** 1.34 ***        
Guanine nucleotide-binding protein subunit beta 2-like 1 GNB2L1   1627 0.76 *** 0.76 ***   0.71 0.70  
Heat shock cognate 71 kDa protein HSPA8   1980 0.73 *** 0.91 .   0.49 0.73  
Heat-shock protein beta-1 HSPB1   1764 0.72 *** 0.84 ***   0.74 0.79  
      2212 0.72 *** 0.77 ***        
Inosine-5′-monophosphate dehydrogenase 2 IMPDH2   2150 0.76 ** 0.87 *   0.78 0.49  
Nucleophosmin NPM1   2026 0.51 *** 0.84 *   0.84 0.76  
Peroxiredoxin-2 PRDX2   1857 1.23 *** 1.20 ***   1.27 1.20  
Peroxiredoxin-6 PRDX6   1762 0.69 *** 0.90 **   0.61 0.57  
Phosphoglycerate kinase 1 PGK1   1373 1.63 *** 1.41 ***   2.78 2.37 Glycolysis
Phosphoglycerate mutase 1 PGAM1   1745 1.39 *** 1.29 **   1.39 1.57 Glycolysis
Prelamin-A/C LMNA   840 1.37 *** 1.46 ***   1.30 1.22  
      845 1.65 *** 1.35 ***        
      851 1.82 *** 1.50 ***        
      2072 1.32 *** 1.06          
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 PLOD2   633 3.25 *** 2.78 ***   5.55 3.13 Iron
Prohibitin PHB   1668 0.85 ** 0.95     0.52 0.48  
Prolyl 4-hydroxylase subunit alpha-1 P4HA1   1049 2.79 *** 2.63 ***   3.21 2.08 Iron
RNA-binding protein 4B RBM4B   1438 1.33 *** 1.19 **   0.95 0.77  
Stress-induced-phosphoprotein 1 STIP1   1011 0.79 ** 0.97     0.67 0.66  
Triosephosphate isomerase TPI1   1786 1.47 *** 1.30 **   1.69 1.27 Glycolysis

In proteomic changes, the mean ratios of identified spots between control and compound-treated cells are listed. Non-repeated-measures ANOVA and Dunnett’s test for post hoc analysis were performed. In transcriptomic changes, the ratio between control and compound–treated cells are listed. If there are more than one probes corresponding to the protein, the mean ratio was calculated. *P < 0.05; **P < 0.01; ***P < 0.001.