Figure 6. Efficacy of topical BC-DETC and intraperitoenal Sb^v combined therapy in L. braziliensis infection.

Mice were infected and three weeks later were treated with topical BC-DETC (at 350 μg/cm²), intraperitoneal Sb^v (100 mg/kg/day) or both. Controls received empty BC. (A) The course of lesion size development was measured weekly. (B) Disease burden [shown as Area Under the Curves (AUC) depicted in (A)] for each group. Parasite load was determined at the infection site (C) and at the dLN (D), 6 weeks after infection, by limiting dilution analysis. Data are from a representative experiment performed with twelve mice per group. *p < 0.05; **p < 0.01; ***p < 0.001.