Figure 1. Increased browning of SAT in obese WT female mice after treatment with LY3201 for 3 days.
(A) Treatment with LY3201 induced multilocular lipid droplets, as shown by H&E staining (red arrow) in e, and UCP1 positive (red arrow) as represented in f–h. All pictures are 20x magnification. (B) There was up-regulation of browning-associated genes by LY3201 in SAT of aged WT female mice. (C) There were no changes in beige-cell-specific genes after treatment with LY3201. *p < 0.05, **p < 0.01, ***p < 0.001, LY3201 vs. Vehicle.