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. 2016 Dec 6;6:38101. doi: 10.1038/srep38101

Table 1. Comparative analyses of various chromosomal HP0539/cagL deletion mutants.

H. pylori strains CagL amount CagL secretiona CagI amount CagH amount CagA amount IL-8 induction in AGS cells CagA translocation
SU2 wt ++ ++ ++ ++ ++ ++ ++
cagL::aphA3 + ++ ++ n.d.
CagLΔTSPSA ++ ++ ++ ++ ++ ++ ++
CagLΔNNEM ++ ++ ++ ++ ++ ++ ++
CagLΔRGD ++ ++ ++ ++ ++ ++ ++
CagLΔELFFI + + + ++ ++ +
CagLΔSEDVI + + + ++ ++ ++ +
CagLΔFKTYM + + + ++ ++ +
CagLΔLDQNT ++ ++ n.d.
CagLΔAEQQC + ++ ++ ++ ++ ++ +
CagLΔGISDK + ++ ++ + n.d.
CagLΔTASLI +(+) ++ ++ ++ ++ ++ ++
CagLΔRGDΔTASLI + + ++ ++ ++ +
CagLΔTSPSAΔRGD + + ++ ++ ++ ++
CagLT170K ++ + + ++ ++ ++ ++

The plus and minus signs in each column indicate: [++], [+(+)] normal to slight reduction, [+] clear reduction, and [−] strong reduction of the respective protein or function (column header) in comparison with the parental strain (reference, SU2 wild type [wt]).

aThe short term “CagL secretion” indicates that CagL was detected in the outer fraction of the bacteria which includes surface-associated material; CagL has been detected before by others on the bacterial surface27,24. n.d. = below detection level.